Original Papers

2019

114: Templated Synthesis of Gold Nanoparticles on Surface-Aminated 2D Cellulose Assemblies
Takatoshi Nohara, Toshiki Sawada, Hiroshi Tanaka, and Takeshi Serizawa*, Bull. Chem. Soc. Jap., 2018, accepted for publication

113: Convergent synthesis of linear and multiple-branched b(1,3)-glucans and an evaluation of their binding affinities to dectin-1
Hiroki Hamagami, Yoshiyuki Adachi, Naohito Ohno, Hiroshi Tanaka*, Asian J. Org. Chem., 2018, accepted for publication

2018

112: D-π-A Dyes Containing Novel Hydantoin Anchoring Groups for Dye-sensitized Solar Cells
Hisashi Masui; Masato M Maitani; Shinichiro Fuse; Ayaka Yamamura; Yuhei Ogomi; Shuzi Hayase; Tatsuo Kaiho; Hiroshi Tanaka; Yuji Wada; Takashi Takahashi, Asian J. Org. Chem., 2018, 7, 458-464

2017

111: Synthesis and biological evaluation of O-methylated glycolipids related to PGLs via direct stereoselective glycosidation and sequential Suzuki-Miyaura coupling using boracyclane
Ko Sato, Zakaria Omahdi, Kensuke Shibata, Koh-hei Sonoda, Sho Yamasaki, and Hiroshi Tanaka* Chem. Eur. J., 2017, 23, 6374–16379.

110: Crystal structure of octocoral lectin SLL-2 complexed with Forssman antigen tetrasaccharide
Akiko Kita, Mitsuru Jimbo, Ryuichi Sakai, Yukio Morimoto, Ryota Takeuchi, Hiroshi Tanaka, Takashi Takahashi, Kunio Miki*, Glycobiology, 2017, 27, 696-700.

109: Enzymatic synthesis and protein adsorption properties of crystalline nanoribbons composed of cellulose oligomer derivatives with primary amino groups
Takatoshi Nohara, Toshiki Sawada, Hiroshi Tanaka, and Takeshi Serizawa*, J. Biomater. Sci., Polym. Ed., 2017, 28, 925-938.

108: PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma
Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Maasa Yamanouchi, Takashi Nojiri, Hiroaki Onda, Jaehoon Bae, Yuhui Huang, Kanako Takamatsu, Shuya Yamashita, Shuhei Yamada, Kenji Kangawa, Takashi Takahashi, Hiroshi Tanaka, and Hirofumi Tachibana, Sci. Rep., 2017, 7, 1917

107: Chemical synthesis and evaluation of a disialic acid-containing dextran polymer as an inhibitor of sialic acid binding immunoglobulin-like lectin, Siglec 7
Sho Yamaguchi, Atsushi Yoshimura, Yu Yasuda, Airi Mori, Hiroshi Tanaka, Takashi Takahashi, Ken Kitajima and Chihiro Sato, ChemBioChem, 2017, 18, 1194-1203-938.

106: Oligomer formation of a tea polyphenol, EGCG on its sensing molecule the 67-kDa laminin receptor
Yuhui Huang, Mami Sumida, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, YoshinoriFujimura, and Hirofumi Tachibana*, Chem. Commun., 2017, 53, 1941-1944

105: Synthesis of End-functionalized Glycopolymers Containing α(2,8) Disialic Acids by π-Allyl Nickel Catalyzed Coordinating Polymerization and Their Interaction with Siglec-7
Shuichi Ohira, Yu Yasuda, Ikuyoshi Tomita, Ken Kitajima, Takashi Takahashi, Chihiro Sato, and Hiroshi Tanaka*, Chem. Commun., 2017, 53, 553-556

2016

104: Total Synthesis of Feglymycin based on a Linear/Convergent Hybrid Approach using Micro-flow Amide Bond Formation
Shinichiro Fuse, Yuto Mifune, Hiroyuki Nakamura, Hiroshi Tanaka, Nat. Commun., 2016, 7, 13491.

103: C-type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection
Kenji Toyonaga, Shota Torigoe, Yoshitomo Motomura, Takane Kamichi, Jennifer M. Hayashi, Yasu S. Morita, Naoto Noguchi, Yasushi Chuma, Hideyasu Kiyohara, Kazuhiro Matsuo, Hiroshi Tanaka, Yoshiko Nakagawa, Tetsushi Sakuma, Masaki Ohmuraya, Takashi Yamamoto, Masayuki Umemura, Goro Mastuzaki, Yasunobu Yoshikai, Ikuya Yano, Tomofumi Miyamoto and Sho Yamasaki, Immunity, 2016, 451245–1257.

102: The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-pyridyl-xanthones for Use as Insecticides Starting from Pyripyropene A.
Shinichro Fuse, Kesuke Matsumura, Kohei Johmoto, Hidehiro Uekusa, Hiroshi Tanaka, Tomoyasu Hirose, Toshiaki. Sunazuka, Satoshi Ōmura, Takashi Takahashi, Chem. Eur. J., 2016, 22, 18450–18455

101: The synthesis of trans-flavan-3-ol gallates by regioselective oxidative etherification and their cytotoxicity mediated by 67LR.
Nana Shiraishi, Motofumi Kumazoe, Shinichiro Fuse, Hirofumi Tachibana, and Hiroshi Tanaka* Chem. Eur. J., 2016, 22, 13050-13053

100: Enzymatic Synthesis of Oligo(ethylene glycol)-Bearing Cellulose Oligomers for in Situ Formation of Hydrogels with Crystalline Nanoribbon Network Structures.
Nohara Takatoshi, Sawada Toshiki, Tanaka Hiroshi, Serizawa Takeshi* Langmuir, 2016, 22 , 18450–18455

99: 6-Azido-6-deoxy-L-idose as a hetero-bifunctional spacer for the synthesis of azido-containing chemical probes.
Hiroki Hamagami, Motofumi Kumazoe, Yoshiki Yamaguchi, Shinichiro Fuse, Hirofumi Tachibana, and Hiroshi Tanaka* Chem. Eur. J., 2016, 22, 12884-12890

98: Synthesis of Asymmetrically Terminal Bifunctionlized Alkanes by Sequential Suzuki-Miyaura Coupling using B-Thexyl Boracyclanes.
Ryota Suzuki, Shinichiro Fuse, and Hiroshi Tanaka* Eur. J. Org. Chem., 2016, 21, 3471-3481

97: Oxidative deamination of serum albumins by (-)-epigallocatechin-3-O-gallate: A potential mechanism for the formation of innate antigens by antioxidants.
Yukinori Hatasa, Miho Chikazawa, Mai Furuhashi, Fumie Nakashima, Takahiro, Shibata, Tatsuhiko Kondo, Mitsugu Akagawa, Hiroki Hamagami, Hiroshi Tanaka, Hirofumi Tachibana, and Koji Uchida PLOS ONE, 2016, 11(4), e0153002

96: The α-Glycosidation of partially Unprotected N-Acetyl and N-Glycolyl Sialyl Donors in the Absence of a Nitrile Solvent Effect.
Taku Aoyagi, Shuichi Ohira, Shinichiro Fuse, Jun Uzawa, Yoshiki Yamaguchi, and Hiroshi Tanaka* Chem. Eur. J., 2016, 22, 6968-6973

95: Synthesis of [123I]-Iodometomidate from a Polymer-Supported Precursor with a Large Excluded Volume.
Chika Nakagawa, Masahito Toyama, Ryota Takeuchi, Takashi Takahashi and Hiroshi Tanaka* RSC Adv., 2016, 6, 12215-12218

94: Rapid Synthesis of D-A'-π-A Dyes through a One-Pot Three-Component Suzuki–Miyaura Coupling and an Evaluation of their Photovoltaic Properties for Use in Dye-Sensitized Solar Cells.
Shunsuke Irie, Shinichiro Fuse,* Masato M. Maitani, Yuji Wada, Yuhei Ogomi, Shuzi Hayase, Tatsuo Kaiho, Hisashi Masui, Hiroshi Tanaka, and Takashi Takahashi* Chem. Eur. J., 2016, 22, 2507–2514

93: Synthesis and Evaluation of Thiophene-based Organic Dyes Containing a Rigid and Non-Planar Donor with Secondary Electron Donors for Use in Dye-Sensitized Solar Cells.
Shinichiro. Fuse, Ryota Takahashi, Masahito M. Maitani, Yuji. Wada, Tatsuo. Kaiho, Hiroshi Tanaka and Takashi Takahashi* Eur. J. Org. Chem., 2016, 21, 508-517

2015

92: Solid-supported reagents composed of a copolymer possessing 2-O-sulfonyl mannosides and phase-transfer catalysts for the synthesis of 2-fluoroglucose
Ryota Takeuchi, Yuki Sakai, Hiroshi Tanaka and Takashi Takahashi, Bioorg. Med. Chem. Lett.2015, 25, 5500-5503

91: A Facile Preparation of α-Aryl Carboxylic Acid via One-flow Arndt-Eistert Synthesis
Shinichiro. Fuse, Yuma Otake,, Yuto Mifune, Hiroshi Tanaka, Aust. J. Chem., 2015, 68(11), 1657-1661

90: Directing Group/Protecting Group-Free Synthesis of Tetraaryl-Substituted Pyrazoles via Four Direct Arylations on an Unsubstituted Pyrazole Scaffold
Shinichiro. Fuse, Taiki Morita, Kohei Johmoto, Hidehiro Uekusa, Hiroshi Tanaka, Chem. Eur. J., 2015, 14370-14375

89: The chemoselective O-glycosylation of alcohols in the presence of a phosphate diester and its application to the synthesis of oligomannosylated phosphtidyl inositols
Shuichi Ohira Yoshiki Yamaguchi, Takashi Takahashi, and Hiroshi Tanaka, Tetrahedron, 2015, 71, 6602-6611.

88: Regio-Selective, One-pot, Three-component Synthesis of 1,3,4- and 1,3,5-Triaryl Pyrazoles from 1- and 2-Aryl-1-Alkenyl Sulfones
Shinichiro Fuse,* Hirotaka Sugiyama, Daisuke Kobayashi, Yusuke Iijima, Keisuke Matsumura, Hiroshi Tanaka, and Takashi Takahashi*, Eur. J. Org. Chem., 2015, 4756-4767.

87: Reagent control of a Birch reduction for the synthesis of 2-deoxyoligosaccharide possessing 1,4-dialkyl hydroquinone.
Sho Yamaguchia, Hiroshi Tanaka*, Takashi Takahashi*, Eur. J. Org. Chem., 2015, 22, 4939-4943.

86: Rapid Synthesis of Thiophene-based, Organic Dyes for DSSCs via One-pot, Four-component Coupling Approach.
Keisuke Matsumura, Soichi Yoshizaki, Masato. M. Maitani, Yuji Wada, Yuhei Ogomi, Shuzi Hayase, Tatsuo Kaiho, Shinichiro Fuse,* Hiroshi Tanaka, and Takashi Takahashi, Chem. Eur. J. , 2015, 21, 9742–9747

2014

85: Toll-like receptors as a target of food-derived anti-inflammatory compounds.
Takahiro Shibata, Fumie Nakashima, Kazuya Honda, Yu-Jhang Lu, Tatsuhiko Kondo, Yusuke Ushida, Koichi Aizawa, Hiroyuki Suganuma, Sho Oe, Hiroshi Tanaka, Takashi Takahashi and Koji Uchida, J. Biol. Chem. , 2014, 289, 32757-32772.

84: Elucidation of the Structure-Property Relationship of p-Type Organic Semiconductors through Rapid Library Construction via a One-Pot, Suzuki-Miyaura Coupling Reaction
Shinichiro Fuse, Keisuke Matsumura, Atsushi Wakamiya, Hisashi Masui, Hiroshi Tanaka, Susumu Yoshikawa, Takashi Takahashi, ACS Combi. Chem., 2014, 16, (9), 494-499.

83: Rapid library synthesis of amphiphiles based on a dioxinone scaffold and identification of nonlamellar liquid crystals
Shinichiro Fuse, Kentarou Nakamura, Yuto Mifune, Hironori Marubayashi, Ichiro Hijikuro, Shuichi Nojima, Hiroshi Tanaka and Takashi Takahashi Synlett, 2014, 25, (19), 2806-2813.

82: Synthesis of N-allyloxycarbonyl 3,5-dihydroxyphenylglycine via photochemical Wolff rearrangement/nucleophilic addition sequence in a micro-flow reactor
Yuto Mifune, Shinichiro Fuse, and Hiroshi Tanaka, J. Flow Chem. , 2014, 4, (4), 172-178.

81: Synthesis of a Landomycinone Skeleton via Masamune-Bergmann Cyclization.
Sho Yamaguchi, Hiroshi Tanaka, Ryo Yamada, Susumu Kawauchi and Takashi Takahash, RSC Adv., 2014, 4, 32241-32248.

80: Synthesis of a phosphatidylinositol dimannoside using 2-(azidomethyl)benzoate mannosyl donors
Shuichi Ohira, Yoshiki Yamaguchi, Takashi Takahashi, and Hiroshi Tanaka, Heterocylcs, 2014, 89, 763-774.

79: Establishment of the absolute configuration of the 34-membered polyol macrolide compound JBIR-129
Teppei Kawahara, Shuichi Ohira, Miho Izumikawa, Hiroshi Tanaka and Kazuo Shin-ya, J. Antibiot., 2014, 67, 419-420.

78: NMR study of short β1,3-glucans provides insights into the structure and interaction with Dectin-1
Shinya Hanashima, Akemi Ikeda, Hiroshi Tanaka, Yoshiyuki Adachi, Naohito Ono, Takashi Takahashi, Yoshiki Yamaguchi, Glycoonj. J., 2014, 31, 199-207.

77: Synthesis of a Dextran-Based Bone Tracer for in vivo Magnetic Resonance and Optical Imagings by Two Orthogonal Coupling Reactions
Hiroshi Tanaka, Sho Yamaguchi, Jun-ichiro Jo, Ichio Aoki, Yasuhiko Tabata and Takashi Takahashi RSC Adv.,2014, 4, 7561-7565.

201376: In situ label-free imaging for visualizing the biotransformation of a bioactive polyphenol
Yoon Hee Kim, Yoshinori Fujimura, Takatoki Hagihara, Masako Sasaki, Daichi Yukihira, Tatsuhiko Nagao, Daisuke Miura, Shinichi Yamaguchi, Kazunori Saito, Hiroshi Tanaka, Hiroyuki Wariishi, Koji Yamada, Hirofumi Tachibana, Sci. Rep., 2013, 3, e2805.

75: NMR study into the mechanism of recognition of the degree of polymerization by oligo/polysialic acid antibodies
Shinya Hanashima, Chihiro Sato, Hiroshi Tanaka, Takashi Takahashi, Ken Kitajima, Yoshiki Yamaguchi Bioorg. Med. Chem. , 2013, 21, 6069–6076.

74: β-Galactosyl Yariv reagent binds to the β-1,3-galactan of arabinogalactan-proteins
Kiminari Kitazawa, Theodora Tryfona, Yoshihisa Yoshimi, Yoshihiro Hayashi, Susumu Kawauchi, Liudmil Antonov, Hiroshi Tanaka, Takashi Takahashi, Satoshi, Kaneko, Paul Dupree, Yoichi Tsumuraya, and Toshihisa Kotake Plant Physiology, 2013, 161, 1117-1126

73: Synthesis and Biological Evaluation of the Forssman antigen Pentasaccharide and Derivatives by a One-Pot Glycosylation procedure.
Hiroshi Tanaka, Ryota Takeuchi, Nami Kuniya, Mitsuru Jimbo and Takashi Takahashi Chem. Eur. J.,2013, 9, 3177–3187

2012

72: Convergent Stereoselective Synthesis of Multiple Sulfated GlcNα(1,4)GlcAβ(1,4) Dodecasaccharides.
Hiroshi Tanaka, Yusuke Tateno and Takashi Takahashi Org. Biomol. Chem., 2012, 10, 9570 - 9582

71: Synthesis of a β-glucan polysaccharide analogue by an iterative copper-catalyzed azide-acetylene coupling reaction.
Hiroshi Tanaka, Hiroaki Tago, Yoshiyuki Adachi, Naohito Ohno and Takashi Takahashi Tetrahederon Lett. , 2012, 53, 4104-4107

70: Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation.
Hiroshi Tanaka, Tetsuya Kawai, Yoshiyuki Adachi, Shinya Hanashima, Yoshiki Yamaguchi, Naohito Ohno and Takashi Takahashi Bioorg. Med. Chem. , 2012, 20, 3898-3914

69: Synthetic Study of the Angular Tetracyclic Core Skeleton of Landmycine A via Masamune-Bergman Cyclization.
Sho Yamaguchi, Hiroshi Tanaka, Ryo Yamada, Susumu Kawauchi, Takashi Takahashi, Synlett, 2012, 23, 1327-1330.

68:Reagent-Controlled Stereoselective Synthesis of (±)-Gallo- and (±)-Epigallo-catechin Gallates
Hiroshi Tanaka, Ayaka Chino, Takashi Takahashi.Tetrahedron Lett., 2012, 53, 2493-2495

2011

67: Transthiocarbamoylation of proteins by thiolated isothiocyanates
Takahiro Shibata, Yuuki Kimura, Akihiro Mukai, Hitoshi Mori, Sohei Ito, Yukio Asaka, Sho Oe, Hiroshi Tanaka, Takashi Takahashi, and Koji Uchida J. Biol. Chem., 2011,286, 42150-42161

66: A fluorous-assisted synthesis of oligosaccharides using a phenyl ether linker as a safety-catch linker
Hiroshi Tanaka, Yosuke Tanimoto, Tetsuya Kawai, Takashi Takahashi. Tetrahedron, 2011, 67, 10011-10016

2010

65: β(1,3) Branched Heptadeca- and Linear Hexadeca-saccharides Possessing an Aminoalkyl Group as a Strong Ligand to Dectin-1
Hiroshi Tanaka, Tetsuya Kawai, Yoshiyuki Adachi, Naohito Ohno, Takashi Takahashi. Chem. Commun, 2010, 46, 8249-8251

64: Solid-phase Synthesis of a Combinatorial Methylated Epigallocatechin Gallate Library and the Growth-Inhibitory Effects of these Compounds on Melanoma B16 cells.
Hiroshi Tanaka,* Maasa Yamanouchi, Haruko Miyoshi, Keisuke Hirotsu, Hirofumi Tachibana, Takashi Takahashi.* Chem. Asian J., 2010, 5, 2231-2248

63: Synthesis of Bicyclic Enediynes That Possess a Photosensitive Triggering Device and Exhibit Strong DNA Cleaving Activity.
Hiroshi Tanaka,* Yoshikazu Tanaka, Masafumi Minoshima, Sho Yamaguchi, Shinichiro Fuse, Takayuki Doi, Susumu Kawauchi, Hiroshi Sugiyam and Takashi Takahashi Chem. Commun. 2010, 46, 5942-5944

62: Developmental stage-dependent expression of a trisialic acid unit on glycoproteins in mouse brain as revealed by mAb.A2B5.
Emi Inoko, Yuji Nishiura, Hiroshi Tanaka, Takashi Takahashi, Koichi Furukawa, Ken Kitajima, and Chihiro Sato. Glycobiology, 2010, 20, 916-928

61: Combinatorial Synthesis of Deoxyhexasaccharides Related to the Landomycin A Sugar Moiety, Based on an Orthogonal Deprotection Strategy.
Hiroshi Tanaka,* Sho Yamaguchi, Atsushi Yoshizawa, Motoki Takagi, Kazuo Shin-ya, and Takashi Takahashi* Chem. Asian J., 2010, 5, 1407-1424,

Selected as most accessed articles 5/2010 in Chemistry - An Asian Journal
Selected as most accessed articles 6/2010 in Chemistry - An Asian Journal
Selected as most accessed articles 7/2010 in Chemistry - An Asian Journal

2009

60: An Efficient Synthesis of a Cyclic Ether Key Intermediate for 9-Membered Masked Enediyne Using an Automated Synthesizer.
Yoshikazu, Tanaka, Shinichiro Fuse, Hiroshi Tanaka, Takayuki Doi and Takashi Takahashi* Org. Process Res. Dev., 2009, 13, 1111-1121

59: Screening and evaluation of new inhibitors of hepatic glucose production."
Motoki Takagi, Junko Hashimoto, Keiichiro Motohashi, Kazutoshi Sakamoto, Seiichi Hashimoto, Maasa Yamanouchi, Hiroshi Tanaka, Takashi Takahashi, and Kazuo Shin-ya J. Antibiot. , 2009, 62, 625-629

58: Stereoselective Synthesis of α(2,9) Di- to Tetra-sialic Acids Using a 5,4-N,O-Carbonyl Protected Thiosialoside.
Hiroshi Tanaka,* Yuji Nishiura, and Takashi Takahashi* J. Org. Chem., 2009, 74, 4383-4386

57: Efficient Synthesis of Deoxysugar Part of Versipelostatin via Direct and Stereoselective Glycosidation and Revision of the Structure of the Trisaccharide Unit.
Hiroshi Tanaka, Atsushi Yoshizawa, Shuhei Chijiwa, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya, Takashi Takahashi* Chem. Asian J., 2009, 4, 1114-1125,

2008

56: An Efficient Convergent Synthesis of GP1c Ganglioside Epitope.
Hiroshi Tanaka,* Yuji Nishiura, Takashi Takahashi* J. Am. Chem. Soc., 2008, 130 , 17244-17245.

55: Efficient Synthesis of an α(2,9) Trisialic Acid by One-Pot Glycosylation and Polymer-Assisted Deprotection.
Hiroshi Tanaka,* Yusuke Tateno, Yuji Nishiura, Takashi Takahashi* Org. Lett. , 2008, 10, 5597-5600.

54: The Synthesis of Carbohydrate Microarrays by S-Alkylation of the Glass-supported 2-Bromoacetamides.
Daisuke Takahashi, Hiroshi Tanaka, Emiko Nakane, Takashi Takahashi Chem. Lett. , 2008, 37, 1252-1253

53: The Synthesis of D-Trihydroxyllysine-Based Oligopeptides as a Hydrophilic Scaffold and its Application to the Synthesis of Bifunctional Chelating Agents for Use as Bone Tracers.
Hiroshi Tanaka, Yoshio Ando, Tsutomu Abe and Takashi Takahashi* Chem. Asian J., 2008, 3, 2033 - 2045.
This paper was hightlighted as Cover Picture: (Chem. Asian J. 12/2008)
Selected as most accessed articles 11/2008 in Chemistry - An Asian Journal

2007

52: Synthesis of 3-O-Acylated Epicatechin Derivatives via Sequential One-Pot Multi-Step Reactions.
Makoto Kitade, Hiroshi Tanaka, and Takashi Takahashi Heterocycles , 2007, 73, 183-185.

51: Solid-Phase Synthesis of Epigallocatechin Gallate Derivatives.
Hiroshi Tanaka, Haruko Miyoshi, Yu-Cheng Chuang, Yoshio Ando, Takashi Takahashi Angew. Chem., Int. Ed. 2007, 46, 5934-5437.

50: Synthesis of Biologically Active Fluorescent-Labeled Aerugonosin Derivatives.
Yoichiro Hoshina, Yoshifumi Yamada, Hiroshi Tanaka, Takayuki Doi and Takashi Takahashi*Bioorg. Med. Chem. Lett., 2007, 17, 2904-2907.

49: Direct and Stereoselective Synthesis of β-Linked 2,6-Deoxy-Oligosaccharides.
Hiroshi Tanaka,* Atsushi Yoshizawa, Takashi Takahashi* Angew. Chem., Int. Ed. 2007, 46, 2505 - 2507.

2006

48: A new mechanism of methotrexate action revealed by target screening with affinity beads
Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki, and Hiroshi Handa, Mol. Pharmacol., 2006, 70, 1832-1839.

47: Efficient Synthesis of (±)-Epigallocatechin Gallate by Reductive Intramolecular Etherification
Makoto Kitade, Yoshiaki Ohno, Hiroshi Tanaka, Takashi Takahashi* Synlett, 2006, 2827-2829.

46: Polymer-Assisted Solution-phase Synthesis and their Neurite Outgrowth-Promoting Activity of 15-Deoxy-Δ12,14-PGJ2 Derivatives.
Hiroshi Tanaka, Tsuyoshi Hasegawa, Hiroko Nakahara, Narumi Kita, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida* and Takashi Takahashi* Chem. Asian J. 2006, 1, 669-677

45: Polymer-Assisted Strategy for the Deprotection of Protected Oligosaccharides
Hiroshi Tanaka, Tadasuke Ishida, Nobatsu Matoba, Hirokazu Tsukamoto, Haruo Yamada and Takashi Takahashi* Angew. Chem., Int. Ed. 2006, 45, 6349-6352

44: Stereoselective Synthesis of Oligo-α(2,8)-Sialic Acids.
Hiroshi Tanaka,* Yuji Nishiura, and Takashi Takahashi* J. Am. Chem. Soc. 2006, 128, 7124-7125.

43: Stereoselective Synthesis of Oligo-α(2,8)-3-deoxy-D-manno-2-octulosonic Acid Derivatives.
Hiroshi Tanaka, Daisuke Takahashi, and Takashi Takahashi* Angew. Chem., Int. Ed. 2006, 45, 770-773.

42: Solid-Phase Synthesis and and Biological Activity of a Combinatorial Cross-Conjugated Dienone Library
Makoto Kitade, Hiroshi Tanaka, Sho Oe, Makoto Iwashima, Kazuo Iguchi, Takashi Takahashi Chem. Eur. J. 2006, 12 1368-1376..

41: Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening
Hisakage Funabashi, Yasuhiro Tanaka, Yoshimasa Imamura, Masayasu Mie, Takashi Manabe, Hiroshi Tanaka, Takashi Takahashi, Hiroshi Handa, Masuo Aizawa and Eiry Kobatake Biosens Bioelectron, 2006, 21, 1675-1683.

40: Affinity Identification of δ-Opioid Receptors Using Latex Nanoparticles.
Makoto Hasegawa, Hiroshi Ohno, Hiroshi Tanaka, Mamoru Hatakeyama, Haruma Kawaguchi, Takashi Takahashi* and Hiroshi Handa.* Bioorg. Med. Chem. Lett., 2006, 16, 158-161.

39: Synthetic Study of α(2,8) Oligosialosides using N-Troc sialyl N-Phenyltrifluoroimidate
Hiroshi Tanaka, Yuji Nishiura, Masaatsu Adachi, and Takashi Takahashi* Heterocycles, 2006, 67, 107-112.

2005

38: Synthesis of DTPA-Conjugated (1,4) Linked 2-Aminoglycosides Varying in the Anomeric Configuration and their MRI Contrast Effect
Hiroshi Tanaka, Yoshio Ando, Masatoshi Wada, and Takashi Takahashi.* Org. Biomol. Chem., 2005, 3, 3311 - 3328.

Top 10 most downloaded OBC articles in September 2005

37: Solid-Supported Sulfonylhydroxylamine as an Effective N-Aminating Agent of Anilines
Hiroshi Ohno,* Hiroshi Tanaka, Takashi Takahashi* Synlett, 2005, 1191-1194.

36: Automated Parallel Synthesis of a Protected Oligosaccharide Library Based upon the Structure of Dimeric Lewis X by One-Pot Sequential Glycosylation
Hiroshi Tanaka, Nobuatu Matoba, Hirokazu Tsukamoto, Hisami Takimoto, Haruo Yamada and Takashi Takahashi. Synlett, 2005, 824-828.

35: Effective One-Pot Synthesis of H type 1 and 2 Trisaccharide Derivatives Using Glycal Epoxide
Hiroshi Tanaka,, Nobuatsu Matoba, and Takashi Takahashi* Chem. Lett. 2005, 34, 400-401.

34: Efficient Stereoselective Synthesis of γ-N-Glycosyl Asparagines by N-Glycosylation of Primary Amide Groups.
Hiroshi Tanaka, Yuki Iwata, Daisuke Takahashi, Masaatsu Adachi, Takashi Takahashi J. Am. Chem. Soc. 2005, 127, 1630 - 1631

33: One-Pot Synthesis of Sialo-Containing Glycosyl Amino Acids Using N-Troc β-Thiophenyl Sialoside
Hiroshi Tanaka, Masaatsu Adachi, Takashi Takahashi Chem. Eur. J. 2005 11 849-862.

2004

32: FR225659-binding Proteins: Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads
Hidetaka Hatori, Tatsuya Zenkoh, Motoo Kobayashi, Yoshihiro Ohtsu, Hiroshi Tanaka, Nobuharu Shigematsu, Hiroyuki Setoi, Motohiro Hino, Haruma Kawaguchi, Takashi Takahashi and Hiroshi Handa J. Antibiotics, 2004, 57, 456-461.

31: Synthesis of Affinity Nanoparticles Coupled to FR901464 Derivatives
Yoshimasa Imamura, Yoshihiro Ohtsu, Hiroshi Tanaka, Mamoru Hatakeyama, Takashi Manabe, Haruma Kawaguchi, Hiroshi Handa, and Takashi Takahashi Heterocycles 2004 64 51-56

30:Design and Synthesis of a Solid-Supported FR225659 Derivative for Its Receptor Screening
Tatsuya Zenkoh, Hidetaka Hatori, Hiroshi Tanaka, Makoto Hasegawa, Mamoru Hatakeyama, Yasuaki Kabe, Hiroyuki Setoi, Haruma Kawaguchi, Hiroshi Handa, and Takashi Takahashi Org. Lett. 2004, 6, 2477-2480
Hot Articles in Organic Letters

29: Efficient Solid-Phase Synthesis of Clavulones via Sequential Coupling of α- and ω-Chains
Hiroshi Tanaka, Tsuyoshi Hasegawa, Makoto Iwashima, Kazuo Iguchi, Takashi Takahashi Org. Lett. 2004, 6, 1103 - 1106.

28: Effective sialylation method using N-Troc and N-Fmoc β-phenyl thiosialosides and an application to the one-pot two-step synthesis of 2,6-STF Antigen.
Masaatsu Adachi, Hiroshi Tanaka and Takashi Takahashi*Synlett 2004, 609-614.

27: Efficient synthesis of core 2 class glycosyl amino acids by one-pot glycosylation approach
Hiroshi Tanaka, Masaatsu Adachi and Takashi Takahashi Tetrahedron Lett. 2004, 45, 1433-1436.

26: Solid-Phase Synthesis of N-Alkylated Naltrindoles using a 3-Nitrobenzyl Safety-Catch Linker
Hiroshi Ohno, Hiroshi Tanaka, and Takashi Takahashi Synlett 2004, 508-511.

25: Effective Irreversible Alkylating Reagents Based on the Structure of Clavulones
Hiroshi Tanaka, Makoto Kitade, Makoto Iwashima, Kazuo Iguchi, Takashi Takahashi Bioorg. Med. Chem. Lett. 2004,14, 837-840.

24: Solid-phase synthesis of carbohydrate cluster on tree-type linker with three types of orthogonally cleavable part
Toru Amaya, Hiroshi Tanaka , Takashi Takahashi Synlett 2004, 503-507.

23: Combinatorial synthesis of carbohydrate cluster on tree-type linker with orthogonally cleavable parts
Toru Amaya, Hiroshi Tanaka ,Takashi Takahashi* Synlett 2004, 497-502.


2003

22: Efficient Solid-Phase Synthesis of Symmetric Norbinaltrophimine Derivatives
Hiroshi Tanaka, Mitsuhiro Moriwaki and Takashi Takahashi Org. Lett., 2003, 5, 3807 - 3809.

21: Parallel Synthesis of Multi-branched Oligosaccharides Related to Elicitor Active Pentasaccharide in Rice Cell Based on Orthogonal Deprotection and Glycosylation Strategy
Hiroshi Tanaka, Toru Amaya, and Takashi Takahashi* Tetrahedron Lett. 2003, 44, 3053 - 3057.

20: Solid-Phase Synthesis of Naltrindole Derivatives Using Fischer Indole Synthesis Based on One-Pot Release and Cyclization Methodology
Hiroshi Tanaka, Hiroshi Ohno, Kuniaki Kawamura, Atsushi Ohtake, Hiroshi Nagase and Takashi Takahashi Org. Lett. 2003, 5, 1159 - 1162.

19: The Synthesis of Disaccharides Containing a 2,3,6-Trideoxysugar by Cyclization and Glycosidation Based on the Sequential Activation of Sulfoxide and Methylthio Groups in a One-pot Procedure
Toru Amaya, Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi* Angew. Chem. Int. Ed. 2003, 42, 1833-1836.

2002

18: Synthesis of Di-branched Heptasaccharide by One-Pot Glycosylation Using Seven Independent Building Blocks
Hiroshi Tanaka, Masaatsu Adachi, Hirokazu Tsukamoto, Takeji Ikeda, Haruo Yamada, and Takashi Takahashi Org. Lett. 2002, 4, 4213-4216.

17 : Solid-Phase Synthesis of 2-(Carbamoylpyrazolyl)-4-Alkylamino-6-Aminopyrimidine Derivatives
Makoto Haruta, Akio Ejima, Hiroshi Tanaka and Takashi Takahashi Heterocycles 2002 58, 79-83.

16: Catalytic Methoxycarbonylation of Aromatic Diamines with Dimethyl Carbonate to Their Dicarbamates Using Zinc Acetate
Toshihide Baba, Akane Kobayashi, Tatsuya Yamauchi, Hiroshi Tanaka, Shinji Aso, Masamitsu Inomata, Yukio Kawanami Cata. Lett., 2002, 82, 193-197.

15 : Solid-Phase Synthesis ofβ-Mono-Substituted Ketone and an Application to the Synthesis of Library of Phlorizin Derivatives.
Hiroshi Tanaka, Tatsuya Zenkoh, Hiroyuki Setoi, Takashi Takahashi* Synlett2002, 1427-1430.

14 : Solid-Phase Synthesis of a Phytoalexin Elicitor-Active Tetraglucosyl Glucitol
Takashi Takahashi,* Akihiro Okano, Toru Amaya, Hiroshi Tanaka, and Takayuki Doi Synlett2002, 911-914.

13 : Solid-Phase Synthesis of Aryl O-Glycoside Using Aqueous Base and Phase-Transfer Catalyst
Tatsuya Zenkoh, Hiroshi Tanaka, Hiroyuki Setoi, Takashi Takahashi Synlett, 2002, 867-870.

12 Solid-Phase Synthesis of 6-Sulfonylamino Morphinan Libraries
Hiroshi Ohno, Kuniaki Kawamura, Atsushi Otake, Hiroshi Nagase, Hiroshi Tanaka, Takashi Takahashi* Synlett 2002, 93-96.

2001

11 : The first synthesis of tetraglucosyl glucitol having phytoalexin-elicitor activity in rice cells based on a sequential glycosylation strategy
Toru Amaya, Hiroshi Tanaka, Takeshi Yamaguchi, Naoto Shibuya and Takashi Takahashi* Tetrahedron Lett. 2001, 42, 9191-9194.

10 : Total Synthesis of (±)-Smenospondiol by Titanium(III)-Mediated Tandem Radical Cyclization
Yamada Haruo, Tsuyoshi Hasegawa, Hiroshi Tanaka and Takashi Takahashi, Synlett 2001, 1935-1937.

9 : Parallel Synthesis of Oligosaccharide Conjugate Enediyness onto Silyl-linked Solid-Support
Akihisa Matsuda, Takayuki Doi, Hiroshi Tanaka, Takashi Takahashi*, Synlett,2001, 1101-1104.

1993-1998

8 : DNA Cleaving Acitivities of 9-Membered Masked Enediyne Analogues Possessing DNA Intercalator and Sugar Moieties
Takashi Takahashi,* Hiroshi Tanaka, Akihisa Matsuda, Takayuki Doi, Haruo Yamada, Takayuki Matsumoto, Daisuke Sasaki, and Yukio Sugiura, Bioorg. Med. Chem. Lett. 1998, 8, 3303-3306.

7 : Synthesis of 9-Membered Masked Enediyne Analogues Possessing DNA Intercalator and Sugar Moieties
Takashi Takahashi,* Hiroshi Tanaka, Akihisa Matsuda, Takayuki Doi, and Haruo Yamada, Bioorg. Med. Chem. Lett. 1998, 8, 3299-3302.

6 : Synthesis of Nine Membered, Masked Enediyne Analogues with DNA Intercalators and Its DNA Cleaving Activities.
Takashi Takahashi, Hiroshi Tanaka, Haruo Yamada, Takuyuki Matsumoto, Yukio Sugiura Angew. Chem., Int. Ed. 1997, 36, 1524-1526.

5 : A New Approach to Nine-Membered Enediyne Using a Palladium Catalyzed Cross- Coupling Reaction.
Hiroshi Tanaka, Akihisa Matsuda, Haruo Yamada, Takashi Takahashi Synlett 1997, 381-383.

4 : DNA Cleavage by Nine-Membered Masked Enediyne, an Analogue of the Kedarcidine and C-1027-Chromophores.
Takashi Takahashi, Hiroshi Tanaka, Haruo Yamada, Takuyuki Matsumoto, Yukio Sugiura Angew. Chem., Int. Ed. 1996, 35, 1835-1537.

3 :Synthesis of 10-Membered Masked Oxaenediyne Analogue of Kedarcidin-chr. and C-1027-chr., and Its DNA Cleaving Activity.
Takashi Takahashi, Hiroshi Tanaka, Akihisa Matsuda, Haruo Yamada, Yakuyuki Matsumoto, Yukio Sugiura Tetrahedron Lett. 1996, 37, 2433-2436.

2 :Stereochemical Analysis of Transannular [2,3]-Wittig Rearrangement of 12-Membered Cyclic Ether Based on Rigid MM2 Transition State Model
Takashi Takahashi, Hiroshi Tanaka, Yasuharu Sakamoto, Haruo Yamada Heterocycles 1996, 43, 945-948.

1 :Synthesis of a Nine-Membered Cyclic Analogue of the Neocarzinostatin Chromophore and Its DNA-Cleaving Activity
Takashi Takahashi*,Hiroshi Tanaka , Yoshimasa Hirai, Takayuki Doi, Haruo Yamada, Takashi Shiraki and Yukio Sugiura, Angew. Chem. Int. Ed. 1993, 32, 1657-1659.